Using Initial Cognitive Symptoms to Predict Trajectories of Neurodegenerative Pathologies
Using a cohort of 2426 participants from the National Alzheimer Coordinating Center, a recently conducted retrospective longitudinal study aimed to see if initial cognitive symptoms had similar rates of function decline across Alzheimer disease pathology (ADP), Lewy body-related pathology (LRP), and mixed ADR-LRP. Data was collected over a mean interval of 5.5 (standard deviation, 2.8) years from initial visit to autopsy, with Clinical Dementia Rating-Sum of Boxes (CDR-SB) score used as the primary outcome.
Linear mixed models adjusted for baseline CDR-SB, age, sex, education, and apolipoprotein (APOE) e4 status were used to evaluate longitudinal outcomes. All told, initial nonamnestic symptoms had a faster rate of functional decline than other amnestic …
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