Study in France suggests high efficacy of mRNA vaccines against SARS-CoV-2 variants of concern

Study in France suggests high efficacy of mRNA vaccines against SARS-CoV-2 variants of concern

A nationwide case-control study conducted in France has assessed the efficacy of mRNA-based coronavirus disease 2019 (COVID-19) vaccines against original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, including B.1.1.7, B.1.351, and P1. In real-life pandemic situations, the two-dose regimen of mRNA vaccines has shown equivalent protective efficacy against the original virus and B.1.1.7 variant and a slightly reduced efficacy against the B.1.351 and P1 variants. The study has recently been published in the journal The Lancet Regional Health – Europe. Background Within one year of the emergence of the COVID-19 pandemic, several potent vaccines were been developed against the original Wuhan strain of SARS-CoV-2. However, with the progression of the pandemic, multiple viral variants with significantly high infectivity have emerged and soon become predominant in many countries worldwide. This has raised global concern about the efficacy of preexisting vaccines against newly emerged viral variants. In real-world pandemic situations, most COVID-19 vaccines have shown equivalent efficacy against the original SARS-CoV-2 and the B.1.1.7 variant, which was first identified in the UK. However, in general, antibodies induced by vaccination …
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