New mechanism involved in early melanoma metastasis discovered
We must not only look inside the tumor but also outside of it."
Héctor Peinado, researcher, Spanish National Cancer Research Centre (CNIO)
How tumors manipulate their environment to advance is one of the big questions that Peinado has been trying to answer for years. For decades "to fight tumors, researchers focused on studying their intrinsic behavior, but not on their surroundings."
Peinado is the head of the CNIO's Microenvironment & Metastasis Group, which studies the mechanisms involved in metastatic progression, including how nanoparticles called exosomes, which are released by tumors, manipulate the tumor microenvironment to favor metastasis. A paper published this week in the prestigious journal Nature Cancer describes how this critical process for melanoma progression occurs: exosomes travel and home to the sentinel lymph node -the lymph node where …
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