IV Vitamin C Fares Poorly in Latest Septic Shock Trial

IV Vitamin C Fares Poorly in Latest Septic Shock Trial

More patients in septic shock who received vitamin C infusions died or experienced greater organ dysfunction than those who received placebo — an unexpected finding that has mystified experts in the field, according an article published in The New England Journal of Medicine. "This was an unexpected finding, and the secondary analyses — which included the evaluation of five biomarkers of tissue dysoxia, inflammation, and endothelial injury measured up to day 7 — did not determine a putative mechanism for harm," say the researchers, led by Francois Lamontagne, MD, associate professor and intensivist at the University of Sherbrooke in Quebec, and Neill Adikhari, MDCM, associate professor in critical care at the University of Toronto. The findings — which come from LOVIT, a randomized, placebo-controlled trial of 863 patients in Canada, …
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